Acceleration of wound healing
Stimulates tissue regeneration
without any evidence of side effects
and resistance development
Inactivates multi-resistant pathogens
New possibilities for an effective wound management
Fighting pathogens – accelerating wound healing
The kINPen® MED plasma jet can be used for a wide range of indications including both acute and chronic wounds. Even wounds that are considered to be beyond therapy may benefit from the positive effect. The kINPen® MED accelerates wound healing based on a three-level effect:
Inactivation of bacteria, fungi and viruses (including multi-resistant germs such as MRSA)
Promotion of the microcirculation, thereby improving the oxygen
and nutrient supply of the tissue
Stimulation of the growth and regeneration processes of the
tissue until possible wound closure
The therapy is mostly painless and may have a relieving effect on pain and itching right from the first treatment. So far, no adverse complications or resistance development have been observed.
Experience from clinical application
At the moment there is a large number of international publications providing evidence of the effectiveness of cold plasma in medical applications. In this context, the kINPen® MED plasma jet is globally among the best validated technologies.
neoplas med now corroborates this competence with the first placebo-controlled, patient blinded prospective study investigating the application of cold plasma in patients with diabetic foot syndrome that will provide further relevant insights on the cold plasma therapy with the kINPen® MED plasma jet.
The wound and the wound healing process
Wound healing is a complex process. Its duration depends on may factors such as the severity of an injury, underlying diseases such as diabetes mellitus, or the age of the patient. Wounds are categorised as acute wounds resulting from external influences such as cuts, falls or abrasions, and chronic wounds lacking healing tendency.
The kINPen® MED plasma jet may present a highly effective therapy alternative especially for chronic wounds that fail to respond to conventional treatment. The plasma jet promotes and supports the wound healing processes and may potentially induce wound closure.
An overview of the wounds described above, of the wound healing phases and the functional and effective mechanism of wound healing is described below.
Wound healing can be divided into has three different phases. The exudation phase (cleansing, inflammation), the granulation phase (repair) and the epithelialisation phase (regeneration). Wound healing is only complete after the conclusion of all three phases.
In acute wounds the healing process is triggered by processes in the body. In chronic wounds this process is impaired, wounds are arrested in the inflammatory state and the wound has not healed even after a maximum of 8 weeks.
Often the causes for this are unknown and the wounds are difficult or impossible to treat. The healing process may take months and years without proper healing.
This is an area for the effective and efficient application of the kINPen® MED plasma jet. It promotes and supports the wound healing processes in chronic wounds and the treatment may lead to a potential wound closure.
Natural healing
1. Exudation phase
Phase of wound cleansing and infection control, the healing process starts
Blood coagulation starts, bleeding is stopped
The wound is clogged by protein (Fibrin)
The body’s defence cells remove dead tissue and germs
2. Granulation phase
Generation of new blood vessels, proteins and collagen fibres
The wound fills with granulation tissue, the wound diameter decreases
3. Epithelialisation phase
Regeneration of the tissue from the wound edges, cells of the upper skin layer (epidermis) grow into the wound (epithelialisation)
This leaves a scar that recedes with time
Chronic wound
1. Exudation phase
The wound healing phase of chronic wounds is disrupted, most of the wounds do not progress further than the inflammation phase
2. Granulation phase
The repair phase is reached only partially, the wound does not heal completely
In a chronic wound, the kINPen® MED promotes and supports the wound healing processes that are usually triggered by the body’s own mechanisms, and it thus contributes effectively to each wound healing phase.
1. Exudation phase
Initiates the healing process
Has an anti-inflammatory and anti-bacterial effect on the wound surface, which can be expected to reduce the risk of new infections
Inactivates a wide range of micro-organisms such as multi-resistant pathogens
2. Granulation phase
Stimulates the generation of new cells down to the deeper skin layers
Improves micro-circulation and thus the supply of the tissue with oxygen and nutrients
Promotes the generation of new blood vessels (angiogenesis), proteins and tissue structures
3. Epithelialisation phase
Stimulates the tissue regeneration processes up to the potential wound closure
Effect of cold plasma on cell types
There are two different types of cells – eukaryotes and prokaryotes. The kINPen® MED plasma jet has the ability to safely inactivate prokaryotic micro-organisms (e.g. multi-resistant pathogens such as MRSA) in case of inflammations, as their DNA is free and unprotected inside the cell. Human cells (eukaryotes) are not affected by its action.
Scientific evidence for cold plasma therapy and the kINPen® MED plasma jet
Cold plasma offers a new and highly effective treatment option for many types of wounds. The anti-microbial, anti-inflammatory and wound healing promoting properties of this innovative form of therapy have been demonstrated in numerous studies. Equally verified: the gentle and mostly pain-free application of the kINPen® MED plasma jet – no resistance development or side effects observed so far.
